COVID-19 pathogenesis – Communicable Diseases Research

SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry

Review

Published on 2022-12-012023-07-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년),

Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of Iran

Article

Published on 2022-11-012022-11-15
Journal: Clinica chimica acta; international journal of cli
[Category] 진단,

[키워드] ACE1 acute respiratory syndrome affecting Angiotensin-converting enzyme Angiotensin-converting enzyme 1 Care case-control study caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 susceptibility death disease enzyme Ethnic groups Factor Frequency Genetic Genotype genotyped Health healthy controls I/D polymorphism Infection Iran KCNIP4 material outcome pandemic pathogen PCR polymorphism Polymorphisms populations Potassium Prognostic factor Protein Region Research Respiratory disease severe acute respiratory syndrome coronavirus 2 severity statistically significant supported survival Variation Voltage-gated potassium (Kv) channel-interacting protein 4.
[DOI] 10.1016/j.cca.2022.09.006 PMC 바로가기

Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid Treatment

Article

Published on 2022-10-112022-11-16
Journal: International Journal of Molecular Sciences
[Category] 유전자 메커니즘,

Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination

Review article

Published on 2022-10-012022-10-05
Journal: International immunopharmacology
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

Upregulation of interleukin-19 in saliva of patients with COVID-19

Article

Published on 2022-09-262022-11-15
Journal: Scientific Reports
[Category] SARS, 바이오마커,

[키워드] adjusted Admission adult COVID-19 patients Analysis asymptomatic patient Autopsy Blood C-reactive protein Comorbidity Concentration Corticosteroid COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patients D-dimer dataset death demographics Diabetes Mellitus disease pathogenesis disease severity expression level ferritin healthy control Hospital stay Inflammation interferon beta lung lung cells marker mechanical ventilation nasopharyngeal swabs Patient patients with COVID-19 plasma protein level receptor Saliva SARS-CoV-2 SARS-COV-2 infection serum severity significantly higher Tocilizumab transcriptomic upregulated with COVID-19
[DOI] 10.1038/s41598-022-20087-w PMC 바로가기

Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19

Article

Published on 2022-09-212022-11-16
Journal: Cells
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] accompanied accompany adaptive B.1.617 Blood caused Characteristics contribute coronavirus disease correlated COVID-19 COVID-19 pathogenesis Cytokine storm Delta delta variant diagnostic dominant Factor Gene Expression gene expression signature high mortality highlight immune immune component immune response immune system Immunity immunological individual Infection Lineage lymphoid molecular monocyte Monocytes mononuclear cell Multiple myeloid cells pathway performed proinflammatory required Revealed risk SARS-CoV-2 SARS-CoV-2 lineage severity signature significant changes in single-cell syndrome targeted therapy therapeutic Transcriptome Transcriptome. understanding variant virus with COVID-19
[DOI] 10.3390/cells11192950 PMC 바로가기

MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

MiRNA-SARS-CoV-2 대화 및 전향적인 항-COVID-19 치료법

Review

Published on 2022-09-152022-09-11
Journal: Life sciences
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 비임상, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse effect adverse effects Affect antiviral response approach approved Biomarker caused Cell signaling chance Clinical significance Comorbidities coronavirus Coronavirus-2 country COVID-19 COVID-19 illness COVID-19 infection COVID-19 pathogenesis COVID-19 patient Critical death detect differential expression disease disease onset disease pathology effort etiology expression FDA focus Host host cell host inflammatory response host miRNA host miRNAs identify Infection life cycle microRNA miRNA miRNAs molecular interaction non-coding RNA offer pathogen Pathogen-host interaction patients with COVID-19 post-transcriptionally quest reduce respiratory respond RNA RNA silencing SARS Coronavirus SARS coronavirus 2 SARS coronavirus 2. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity Signaling target gene the SARS-CoV-2 virus therapy treat Treatment Viral viral miRNA viral miRNAs
[DOI] 10.1016/j.lfs.2022.120761 PMC 바로가기 [Article Type] Review

Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

Article

Published on 2022-09-142022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커,

[키워드] abundance acute phase acute respiratory syndrome Alter Analysis approach approach assays body mass index C-reactive protein circulating clinical decision Compromised coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patient creatinine criterion Critical Critically ill cut-off value determine disease disrupt driven by dysregulation energy-related metabolites evaluated Extracellular fluorometric quantification Glucose Health Host Host immune response immune response implicated IMPROVE Increased independent predictor Infection Lactate mechanisms metabolism metabolite metabolomics mitochondrial outcome outcomes Patient Potential biomarker Prognosis Prognostic marker provided pyruvate quantification Quantitative recruited risk SARS-CoV-2 SARS-COV-2 infection semi-targeted metebolomics. serum severe COVID-19 illness severity Signaling Stratification Support validation cohort virus
[DOI] 10.3389/fimmu.2022.912579 PMC 바로가기

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Article

Published on 2022-09-062022-11-15
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 진단,

[키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq single-cell RNA-seq. Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection
[DOI] 10.1073/pnas.2120680119 PMC 바로가기

SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesis

SARS-CoV-2 감염 유발 성장 인자는 COVID-19 발병 기전에서 다른 역할을 합니다

Article

Published on 2022-09-012022-09-11
Journal: Life sciences
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] adverse effect adverse effects angiopoietin association COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Critically ill cytokine Cytokine storm Cytokine storms Cytokines D-dimer disease dysregulation EGF elevated Endothelial dysfunction EPO erythropoietin exhibited G-CSF growth factor Growth factors HGF Hospitalized ICU Inflammation Injury inverse correlation investigation marker moderate Myoglobin negative correlation non-ICU occur P-selectin Pathogenesis pathogenesis of COVID-19 pathophysiology PDGF plasma positive correlation reflected remained repair SARS-COV-2 infection selectin specific disease Thromboembolism tissue tissue injury Tissue injury. upregulated vague VEGF was performed
[DOI] 10.1016/j.lfs.2022.120703 PMC 바로가기 [Article Type] Article